Datum VA-NR Veranstaltung  

Safety & Selectivity in the Scale Up of Chemical Reactions

Ort: Frankfurt am Main
Referent: Dr. Will Watson
Art: FB

vom 19.04.2018 bis 20.04.2018


Tel.: +49 69 7917-364/-291
Fax: +49 69 7917-475

The aim of the course is to give lab chemists an understanding of the issues that need to be considered during the early stages of scale up to large laboratory scale equipment (10-20 litre vessels) / kilo lab. The course will concentrate on chemical safety and selectivity issues and include information on what safety testing equipment is available and the uses and limitations of this equipment. Attendees will learn how to identify potential problems whether they be thermal hazards or selectivity issues. Methods used by other companies for handling hazardous reagents and reactions will be described as well as alternative chemistry to circumvent these reactions and/or reagents.

Detailed Course Contents:
1. Introduction
a. The safety literature
2. Improving safety and selectivity in chemical reactions
a. Inherent safety, choosing the right synthetic route
3. Thermal Hazard Testing and Runaway Reactions
a. Principles of hazard testing – equipment and uses
4. Solvent Selection and Solvent Effects
a. The effect of solvents on chemical reactions
5. Oxidation and reduction
a. Safety issues
6. Hazardous Reactions and Reagents
a. Azides, diazo compounds, Grignard Reagents
7. Work Up
a. Quenching reactions / reagents
8. Scaling up chemical reactions
a. What can go wrong – it’s not what you do but the way that you do it
b. Simple do’s and don’t’s
9. Case studies
a. Vilsmeier reaction, Grignard reaction, Azide chemistry

Any laboratory chemist involved in the scale-up to large scale equipment/kilo lab

Gebühr für Mitglieder: 1.380 EUR

Gebühr für Nichtmitglieder: 1.460 EUR

zuletzt geändert am: 06.11.2017 17:35 Uhr