Swapping aromatic rings with small-ring hydrocarbon cages is a promising method for synthesising more effective drugs. Until recently, however, this tactic was restricted to the replacement of para-substituted phenyl groups. Now, two new methods describe reliable syntheses of a motif for exchanging meta-substituted benzene rings, ushering a new cage-motif into the mainstream and thus opening up opportunities for medicinal chemists. Substituted benzene rings are frequently found in natural products and drug molecules. In the effort to develop more effective medicines, chemists have begun exploring the replacement of these aromatic rings with s...