Metal-organic frameworks (MOFs) are an emerging family of porous solid-state materials exhibiting huge potential for various technological applications (gas storage/separation, catalysis, drug delivery, sensing, etc.). These compounds are composed of inorganic building units (typically d-block metal ions, metal-(oxo/hydroxo)-clusters) which are interconnected by multidentate organic linkers to generate two- or three-dimensional extended networks, exhibiting huge internal surface areas and pore volumes. In this talk, I present our recent efforts in different areas of MOF chemistry. Firstly, I introduce flexible MOFs, which undergo dramatic structural changes as a function of guest molecule adsorption/desorption, temperature or mechanical pressure. By chemical modification or exchange of the frameworks’ building units, the structural response of the MOF can be tunes systematically. Secondly, I demonstrate the preparation of liquid MOFs and their corresponding glasses. MOF glasses represent a new class of glassy materials and own intrinsic porosity, similar to their crystalline parent compounds. We revealed that MOF glasses are able to adsorb even relatively large hydrocarbon gas molecules, thus enabling kinetic gas separation (i.e. the separation of propylene from propane). Finally, I present a new concept for the design of porous framework materials that can be processed (i.e. drop casted, crystallized, etc.) from aqueous solution. Our materials design strategy is based on amphiphilic organic building blocks which reversibly assemble/disassemble to micellar porous frameworks, mediated by coordination to alkali ions in aqueous solution.