In this method, selective synthesis of α-thiocyanate and α-selenocyanate ketones has been reported by metal-free ketonization of vinyl azides with potassium persulfate. The room temperature process enhances sustainability, offering a greener more efficient approach to organic synthesis while eliminating metal dependency, highlighting its academic and environmental significance in advancing cleaner chemical methodologies.

Abstract

The development of a highly effective regioselective ketonization of vinyl azides advancing α-thiocyanated ketones without transition metals using potassium persulfate as a promoter represents a significant milestone in organic synthesis. This innovative technique enables the direct incorporation of a thiocyanate group (─SCN) into specific positions of vinyl azide compounds advances the synthesis of α-thiocyanated ketones, all without the necessity of other catalyst. The reaction utilizes a combination of potassium persulfate with potassium thiocyanate, allowing for straightforward execution at room temperature under normal atmospheric conditions. The presented protocol not only advances the field of α-thiocyanated ketone synthesis but also contributes to greener and more sustainable synthetic strategies.