One‐Pot Regioselective γ‐Trifluoromethylthiolation and γ‐Methylthiolation of Enals

In this article, the direct γ-sulfenylation of enals is reported for the first time. Following this one-pot protocol, A wide variety of γ-trifluoromethylthiolated and γ-methylthiolated enals are readily prepared in up to 82 % yield with a full γ selectivity.

Abstract

We describe herein the direct electrophilic γ-trifluoromethylthiolation and γ-methylthiolation of enals, via the in situ formation of the corresponding silyl dienol ether. This one-pot process is carried out under simple and mild reaction conditions and is compatible with a variety of functional groups.