ARTIKEL
One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a ]quinolin‐5(6H )‐ones from 1‐(2‐Ethynylphenyl)‐1H ‐indoles
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fplaceholder.d488439a.png&w=3840&q=75)
We present a method for the synthesis of substituted indolo[1,2-a]quinoline-5(6H)-ones starting from 1-(2-ethynylphenyl)-1H-indoles. The transformation involves gold-catalyzed oxidation of the triple bond followed by acid-promoted intramolecular cyclization at the indole C2 position. Demonstrating noteworthy versatility, the reaction tolerates a wide array of substituents on the indole core and proceeds in good to excellent yields (up to 93%).
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Fnadc20264160541_gra_0001_a_b79b5130f5.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_nadc20264160250_fig_0001_a_629b285708.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_nadc20264160375_fig_0001_a_375011f964.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_nadc20264160251_fig_0001_a_90516ca1b6.png&w=256&q=75)
![One‐Pot Gold/Acid‐Catalyzed Synthesis of Indolo[1,2‐a
]quinolin‐5(6H
)‐ones from 1‐(2‐Ethynylphenyl)‐1H
‐indoles](/_next/image?url=https%3A%2F%2Fcdn.gdch.de%2Fprod%2Flarge_Adobe_Stock_1952534513_DESIGN_LINE_B22_F08418_D6_F4_DEF_9_D9_F9_F440_EF_54865_c0aab04b38.jpeg&w=256&q=75)
