Photocatalytic hydro-difluoromethylaton of unactivated alkenes has been developed using a commercially available difluoromethylating reagent (CF₂HSO₂Na). This methodology tolerates a variety of functional groups and allows late-stage modification of various alkenes derived from pharmaceutically relevant drugs.

Abstract

In the present manuscript, we have reported a general catalytic strategy that allows the synthesis of a variety of difluoro methylated alkanes from the corresponding unactivated alkenes using commercially available radical difluoromethylating reagent (CF₂HSO₂Na) under visible light photocatalysis. Further, this strategy allows the late-stage modification of various alkenes derived from pharmaceutically relevant drugs.