This work details the methodology for the synthesis of block copolymer nanoparticles through continuous flow self-assembly and purification via flow dialysis. Nanoaggregates are formed by mixing block copolymer solutions in THF with water, followed by dialysis to eliminate excess solvent.

Abstract

Block copolymer self-assembly into nanoparticles of defined size and morphology is facilitated via continuous flow synthesis methods. Using flow, nanoparticles are obtained at higher rates, with improved consistency, under greener conditions and with significantly reduced batch-to-batch variability when compared to traditional batch processes. The methodology to formulate block copolymers in a flow setup is described, and design strategies explained. Further, the purification of the obtained particles via flow dialysis is described, marking a second important step in synthesis, which when performed in batch is time and resource intensive. The described methods open the pathway for reproducible block copolymer nanoparticle synthesis, and towards automation and high-throughput screening of materials.